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KMID : 0855520100230040207
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Korean Journal of Physical Anthropology
2010 Volume.23 No. 4 p.207 ~ p.215
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Low Dose Treatment of RhTGF-β1 Restore the Wound Healing Defect in Dexamethasone-treated Rats
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Kang Ki-Young
Kim Hyun
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Abstract
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Transforming growth factor-β1 (TGF-β1) has chemotactic effect to monocytes, macrophages and fibroblasts, and it stimulates those cells to produce growth factors and collagen fibers. Therefore, TGF-β1 plays important roles in the wound healing process. The aim of this study is to evaluate the effects of recombinant human TGF-β1(rhTGF-β1) on the wound healing defect in dexamethasone-treated rats.
Dexamethasone (0.1 ㎎/㎏/day) was subcutaneously injected into the eight-week-old Sprague-Dawley rats. At the third day of dexamethasone administration, full thickness wounds were made on the back of the rat. And then, rhTGF-β1 (50 ng/wound) was intradermally injected in the vicinity of the wounds. The wounds of the normal and the negative control groups were provided with vehicle only. At 1, 3, 5, 7 and 15 days after the surgery, the wound sizes were measured and the wound tissues were obtained and analyzed.
The mean wound sizes of the rhTGF-β1 injected groups were significantly smaller than those of the negative control groups. Moreover, the histologic findings such as cellular infiltration, re-epithelialization and granulation formation and expression patterns of TGF-βs during the wound healing process were improved by administration of rhTGF-β1. These results support that rhTGF-β1 can restore wound healing defect due to dexamethasone administration.
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KEYWORD
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rhTGF-β1, TGF-β, Wound healing, Dexamethasone
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